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Mepivacaine vs Bupivacaine Spinal Anesthesia for TKA

Kyle Adams - Kyle.Adams@prismahealth.org

ALL
18 years and over
PHASE4
This study is NOT accepting healthy volunteers
NCT06291727
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Inclusion Criteria:
* Patient is at least 18 years of age who are scheduled for a primary elective TKA. * Patient can ambulate at least 10 feet independently without human assistance. * Patient must be a candidate for same day discharge as determined by American Society of Anesthesiologists (ASA) Physical Status Classification I and II
Exclusion Criteria:
* Patients scheduled for bilateral TKAs * Contraindication to spinal anesthesia * Revision TKAs * Allergy or contraindication to NSAIDs (e.g. chronic anti-coagulant use) * Workers' Compensation patient * Type I Diabetes * Type II Diabetes requiring insulin medication. * Pre-operative narcotics use with the exception of tramadol. * Renal insufficiency (GFR \< 60) that may impact post-operative protocol * Cognitive deficiencies that prevent the patient from providing their own informed consent * Language barrier preventing completion of study forms in English
DRUG: Mepivacaine, DRUG: Bupivacaine
Anesthesia, Spinal, Arthroplasty, Replacement, Knee
knee arthroplasty, spinal anesthesia, same day discharge, mepivacaine, bupivacaine
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